A sweet tale: the son who reinvented sugar to help diabetic dad

The natural substitute helps diabetics, combats obesity and tackles climate change writes Senay Boztas in The Guardian



 

Javier Larragoiti (centre) and his Xilinat team in the lab in Mexico City. Photograph: Courtesy Xilinat


Javier Larragoiti was 18 when his father was diagnosed with diabetes. The teenager had just started a degree in chemical engineering in Mexico City. So he dedicated his studies to a side project: creating an acceptable alternative to help his father and millions of Mexicans like him avoid sugar.

“It’s only when you know someone with this sickness that you realise how common it is and how sugar intake plays a huge role,” he says. “My dad tried to use stevia and sucralose, just hated the taste, and kept cheating on his diet.”

The young chemist started dabbling with xylitol, a sweet-tasting alcohol commonly extracted from birch wood and used in products such as chewing gum.

“It has so many good properties for human health, and the same flavour as sugar, but the problem was that producing it was so expensive,” he says. “So I decided to start working on a cheaper process to make it accessible to everyone.”Quick guide
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Ten years later, Larragoiti has patented a fermentation-based process to turn wasted corn cobs from Mexico’s 27.5m-tonne annual crop into xylitol. It is thereby solving a second problem: what to do with all that agricultural waste that otherwise might be burned, adding greenhouse gases to the overladen atmosphere.

His business, Xilinat (pronounced Hill-Ee-Natt), buys waste from 13 local farmers, producing 1 tonne of the product a year. This month his invention was awarded a prestigious $310,000 Chivas Venture prize award, which will enable him to industrialise production and scale up production tenfold.

Obesity is one of the fastest-growing global health problems. One in seven people are obese and about 10% have type 2 diabetes. Since 1980 the rate of obesity has doubled in more than 70 countries.

Larragoiti says that sugary diets are a real problem in Coca-Cola-lovingMexico, which has the world’s second-highest rate of obesity and has successfully taxed sugary drinks to try to combat a main source of the issue.

Paradoxically, another corn byproduct – fructose – is part of the problem, used to make corn syrup that has been linked to increasing obesity in the US.

“It’s kind of ironic,” Larragoiti says. “High fructose corn syrup is just a bomb of carbs and concentrated sugar that makes a high peak of insulin. It’s many times sweeter than regular glucose. Companies use and pay less and that’s the issue.”

Reusing agricultural waste is rapidly emerging as a promising sector for social entrepreneurs keen to tackle global heating and make useful things at the same time.

“One corn stalk has 70% to 80% waste by weight when you get down to it,” says Stefan Mühlbauer, the chief executive of the Sustainable Projects Group Inc. His company has a pilot plant in Alsace, France, and is building another in Indiana, US, to turn corn waste into a peat moss substitute and a super-absorbent foam for filters or soil. “Farmers are excited as it gives them something that extends their harvest season and they see another source of revenue,” he adds.

In Mexico, agricultural waste is often burned, releasing greenhouse gasesand creating one of the country’s highest sources of dioxin emissions. “Burning the residue is cheap and quick and may suppress pests and diseases,” says Dr Wolter Elbersen, a crop production expert at Wageningen University & Research. “The disadvantages such as air pollution, loss of organic matter and nutrients are less appreciated apparently. Removing the material for feed or compost, or added value products such as paper pulp or fuels is often not cost-effective, or no labour is available to do all the work in a short window of time.”

But thinking in a different way about “waste products” is essential if we are going to conserve scarce resources and feed a growing population, according to the Ellen MacArthur Foundation. “We need to think about the principles in the past, where we had to do much with little, and at the same time apply the technology we have at hand nowadays to succeed in the challenge of feeding the world,” says Clementine Schouteden, who leads the global initiative on the circular economy for food at the campaigning organisation.

“There’s definitely a sense of urgency in making sure that we farm in a way that is regenerative, preventing waste but also [creating value from] the waste that is currently not edible, with a food industry making the right options for consumers and for the planet.”

Xilinat’s idea has huge potential, according to Sonal Shah, the founding executive director of the Beeck Center for Social Impact + Innovation at Georgetown University, and a Chivas Venture judge. “It’s not just that he’s building a sugar substitute that tastes like sugar but that it’s going to become scalable so every company that uses sugar in its food has the opportunity to rethink what kind of substitute they use,” she said.

Ebersen added, though, that “you do, however, need a solution for using the leftovers after the xylose has been extracted and the demand for xylitol is small [currently] compared with the amount of residue”.

Meanwhile, what about Javier’s father? “My dad is super-happy,” Larragoiti says. “He uses my product every day and he’s willing not to cheat on his diet any more!”

Injection drug which claims to help people lose more weight than they would by dieting or exercising could soon be available through the NHS

by Patrick Sawer in The Telegraph

A treatment of injections that can help people lost a stone more than they normally would by dieting or exercising more has been approved by health watchdogs.

Liraglutide, which has been described by doctors as life-changing, could be available on prescription in months.

Slimmers typically lose almost a stone more than they would by simply watching how many calories they consume and doing more exercise.

Trials showed that some severely obese patients lost so much weight they were able to abandon their wheelchairs and walk normally for the first time in years.

Liraglutide also lowers blood pressure, raises good cholesterol and prevents diabetes. 

According to its makers, Novo Nordisk of Denmark, the drug even produces a 'feel-good factor', making dieting a pleasure.

But some experts have already warned it does not provide a long-term solution to the growing problem of obesity in Britain.

Novo Nordisk will apply for it to be prescribed on the NHS after Friday’s ruling by the European drugs regulator that it is safe and effective.

There are fears however that Nice – Britain’s drugs rationing body – will judge it too expensive for routine use on the NHS.

Liraglutide costs from £2.25 a day, which is roughly double the price of Orlistat, the only other prescription diet drug.

Patients inject the drug into their stomach before breakfast every day. It works by suppressing appetite.

Liraglutide, which will be given the brand name Saxenda, is already used at a lower dose to treat diabetes. It is based on a hormone found in the gut and sends signals to the brain that trick it into feeling full.

As a result, people eat 10 per cent less food than normal.

Trials of Liraglutide found that men and women who injected themselves daily lost an average of 19lb in 12 months. This is almost a stone more than they would lose by being on a diet and increasing the amount they exercise.

Furthermore one third or those who took part in the trials shed 23lb – more than a stone and a half. For a 14 stone woman that kind of weight loss would usually mean dropping two dress sizes.

The drug which, like insulin, comes in an injectable pen, also has such a significant effect on blood pressure that patients can dispense with the drugs they use to keep it under control.

Like Orlistat, its prescription is likely to be limited to those who are obese or who are overweight and have another health problem such as high blood pressure.

Mike Lean, professor of human nutrition at Glasgow University, told the Mail: "Liraglutide is absolutely life-changing for many of our most difficult-to-manage patients. Most do well, and some amazingly well. And it is extraordinarily safe, at least over the two to three years for which we have good evidence, with no signals to suggest serious side-effects.

"The only real downside is that it is jolly expensive."

Professor Jason Halford, former president of the UK Association for the Study of Obesity, said: "It is potentially very exciting. The real benefit of it is that it is targeting appetite. It strengthens the effects of satiety."

Obesity levels have doubled over the past two decades, making the UK the second-fattest nation in Europe.

Extensive research has found that being obese can lessen person's lifespan by as much as nine years and raise the risk of a host of health problems including diabetes, heart disease, stroke and cancer.

Tests have shown that dieters taking liraglutide lose almost twice as much weight as those on Orlistat.

However, Professor Iain Broom, director of the Centre for Obesity Research at Robert Gordon University in Aberdeen, said that drugs were never going to provide a long term answer to obesity.

He said: "Until society changes and the Government’s relationship with the food industry changes and the food industry itself changes, we are not going to get anywhere very fast."

The European Commission is expected to approve the drug’s licence within the next two months, paving the way for it to go on sale. Novo Nordisk says it could be launched in Europe, including the UK, this year.

Old Conservative Values

Norman Tebbit in The Telegraph

It is all too easy for a blogger to respond a bit too much to the headlines of the day, so every now and again I think it useful to stand back and look at some long-term trends.


David Cameron used to speak about Britain's broken society, and even Ed Miliband makes socialist noises about society from time to time. The Lib Dems concede, too, that there are some deep-rooted problems facing any government which could not be solved by handing everything over to Brussels.
I know well enough that as a man of eighty years, if I say that many things were better in our society when I was young, those who never knew those years will condemn me as an addled old fool living in the past. Should I suggest that if a new way of organising things is clearly not working, and we might revert to the old way which did, some of the “all change is for the better” brigade will denounce me as a mindless reactionary incapable of progressive thought.

Yet the essence of Darwinism is not just that the new shall replace the old. The species that makes the wrong change in response to a changed environment suffers the same fate as that which does not change at all. For all that, there are a good many successful species which have scarcely changed at all for many millions of years.

In our human case the right approach must be the classical conservative approach. That is, when it is not necessary to change, it is necessary not to change. In recent years we have had too much gratuitous change, which has relentlessly divorced the consequences of actions from those actions themselves.

This has happened at all levels of human conduct.

Being fat used generally to be caused by eating too much. Nowadays obesity is generally a medical condition or an “epidemic”. Stealing from shops used to be theft. These days it is at worst shoplifting or a civil offence, or “a cry for help”. Sometimes no doubt it is a cry for help… but not all the time.

As we saw last summer, a crowd smashing into a shop, taking the stock and setting fire to the building may these days no longer be breaking and entering, conspiring to commit theft, violent disorder and arson so much as making “a political statement”.

Despite a rising level of expenditure on education we face a rising tide of illiteracy, innumeracy, and ignorance of science and history amongst school-leavers. Could it be that the cult of child-centred education is a failure? When bright pupils are held back less, the slow ones will follow – because they won't want to be left far behind. More to the point, if we're not stretching bright pupils in the classroom, they'll find some extracurricular activity (perhaps gang leadership) at which to excel anyway.

Why, we might well ask (as Duncan Smith has done), do we have these days hereditary unemployment in families where for two or three generations no one has ever been gainfully and legally employed?

Is it possible that we have constructed a world full of perverse incentives in which it is often the case that immediate gratification, even if not long-term benefit, is most easily achieved by anti-social behaviour? If so, might it not be a good idea to think about reverting to past ways of dealing with such things. After all, was a classroom in which corporal punishment was available, but in my experience seldom used, better or worse than one in which teachers may be physically attacked and teaching takes second place to just keeping a semblance of order?

Nor are such thoughts confined to the behaviour of the financially or socially disadvantaged. The excesses of bankers might have been more quickly changed for the better had rather more of them faced the criminal justice system. Nor can politicians escape their responsibility for creating a belief that the answer to the question, “should I do this?” is no more than “yes, if I can I get away with it”.

Perhaps my views are shaped not just by growing up in rather hard times, but by my profession as a pilot. We aviators learned the inexorable laws of aerodynamics and of the frequently fatal consequences of the pretence that they could be scoffed at, ignored, or changed. And we learned to pay heed to those who had survived longer than us in that unforgiving environment.

The DEVELOPMENT Deception

By Brendan P O'Reilly

Speaking Freely is an Asia Times Online feature that allows guest writers to have their say. Please click here if you are interested in contributing.

"At present, we are stealing the future, selling it in the present, and calling it GDP."
- Paul Hawken

There is a dangerous lie that permeates the media, government and general discourse of nearly every single nation on Earth.

That lie is the Development Deception. This myth is based on three concepts. First is the distinction between the developed nations (North America, Western Europe, Australia, New Zealand, South Korea, and Japan), and the Developing Nations (everywhere else).

The second idea is that "developing" countries can become "developed" through improved education, stable governance, and opening their markets to trade and investment. The third leg of this Deception is that such a transformation is not only possible, but also desirable.

The metric used to distinguish "developed" nations from "developing" nations is gross domestic product (GDP) per capita. Poor nations aspire to reach a certain economic level to become so-called "developed nations". The Myth of Development has four fundamental inter-related flaws. The first one is the problem of the Gray Area.

The gap between "developed" and "developing" countries is presented as a simple black-and-white dichotomy. I often hear from my Chinese students say, "China is a developing country. America is a developed country. We want to become a developed country."

Fair enough. But which country has high-speed trains? Which country has a higher unemployment rate? How can the government of a "developed" country owe trillions of dollars to a "developing" country?

Obviously many nations in Asia and Africa, and Latin America have very serious structural problems, which could be alleviated through stable government and educational reform. Very poor countries should aspire to create social and economic institutions that allow their people to live with dignity. Nevertheless the rise of new economic powers such as Brazil, India, and (especially) China, coupled with the massive financial difficulties faced by Europe, Japan, and the United States, call into question the utility of the developed/developing dichotomy.

The second problem with the Myth of Development is philosophical. The very term "development" implies a steady linear progression from poverty and ignorance to wealth, literacy, and general happiness. This viewpoint is Western in origin, and alien to many of the world’s cultures.

The idea of the inexorable march of progress has roots in the Judeo-Christian worldview of time (God creates the world, the world exists, the world ends), and has been largely co-opted by modern science. We are told to believe that progress is inevitable, that the quality of life for each new generation will be better than the life of their parents. Never mind the fact that humanity has created weapons that empower a handful of political leaders to destroy civilization itself.

Never mind obesity is now challenging starvation as a cause of premature death. Of course, the advances made in the last century in curing diseases, increasing literacy rates, and fighting hunger must be lauded. However, to blindly value "progress" above all else threatens our very survival as a species.

The third problem with the Development Deception stems from definitions. As mentioned previously, GDP per capita is the standard the yardstick for measuring development. This assessment ignores serious social difficulties faced by the so-called developed nations.

For example, a third of the adult population of the United States of America, the archetype "developed" nation, suffer from obesity, with another third classified as overweight. The United States of America also has the dubious distinction of having the highest incarceration rate of any nation on Earth.

Meanwhile Japan, the paragon of "development" in Asia, has one of the lowest fertility rates in the world, leading to a rapidly aging population. This trend, unless dramatically reversed, will exacerbate Japan’s social, economic, and political crisis, as more retirees put enormous strain on the working population. Japan’s population is set to shrink by roughly thirty million over the next four decades (Citation here). Are these worthy goals for the so-called "developing" nations to aspire to?

The fourth and final problem with the Myth of Development is a terminal defect. Citizens in countries such as China and India are encouraged to join the middle class and live "Western" lifestyles. As benign as it sounds, this goal is completely impossible. Simply put, there are not enough natural resources on this planet to sustain such an increase in consumption.

According to World Bank figures, in 2008 Americans, on average, used 87,216 kilowatt hours of electricity. The average Chinese used 18,608 kilowatt hours, and the average Indian 6,280. All three countries depend primarily on coal for electricity. To bridge the gap between these levels of resource utilization of would entail environmental catastrophe and global shortages on an unimaginable scale. Coal is just one example - one could also look at oil, lumber, or meat consumption. Indeed, many of the fundamental challenges facing the world economic system - such as rising food and fuel costs - are directly related to economic development.

The Development Deception is perpetuated by international corporations and national governments. Resource mining, production, and overconsumption are the basis for the current globalized economic system. Human beings are classified as "consumers", because overconsumption entails short-term profit.

Rich nations leverage their "developed" status to influence poorer nations, while the governments of these poor nations use the promise of development to maintain political power. None of this propaganda changes the fact that it is grossly misleading for the nations who over-consume the Earth’s finite resources to be considered developed.

Advocates of The Development Myth may point to science as a savior. We are constantly told that new inventions will allow for more efficient use of resources, or allow for sustainable consumption patterns. This argument provides only false hope. We cannot speculate our way out of environmental pollution and a collapsing natural resource base. Unless and until new "green" technology actually exists and is utilized, science is actually exacerbating ecological disaster.

Recently, the Human Development Index (HDI) has been promoted as a more "human-centered" alternative to GDP as a metric for measuring development. HDI uses data on life expectancy, literacy, number of years in school, and GDP to determine the development status of a country. Although this presents a useful alterative, the continued use of GDP as a basis for measuring development is HDI’s fundamental flaw. Unsustainable consumption of finite resources cannot reasonably be classified as "development".

What is the viable alternative to the Development Myth? Bhutan has advocated Gross National Happiness as an alternative goal to increasing GDP per capita. Citizens are asked about their Subjective Well Being in order to establish Gross National Happiness. Obviously this measurement is difficult to define and numerate, and ignores problems such as illiteracy and extreme poverty. However, it does point in the right direction.

Development needs to be redefined in order to account for human physical and emotional well-being as well as environmental sustainability. Otherwise it is only a lie, and a dangerous one at that. To seek economic advance at the expense of human interests and future generations is a recipe for global disaster.

When extreme wealth is challenging extreme poverty as the bane of human existence, a revolution of values is needed. We as a species must advance values of conservation, and teach people to live within the means of the productive capacity of our planet. No longer can the scramble for nonrenewable resources be viewed as a zero-sum game. Human beings need to develop solidarity on a global scale. Citizens of wealthy nations must learn to live with less.

The most important development is that of the individual. Social and spiritual harmony is the antidote to the Development Deception, for all traditions encourage compassion and warn of the destructive power of greed. To quote LaoZi (as translated by D C Lau):

There is no crime greater than having too many desires;
There is no disaster greater than not being content;
There is no misfortune greater than being covetous.
Hence in being content, one will always have enough.

Brendan P O'Reilly is a China-based writer and educator from Seattle. He is author of The Transcendent Harmony.