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Showing posts with label medical. Show all posts
Showing posts with label medical. Show all posts

Tuesday 4 August 2020

Using HCQ for Covid - Is it Cheating the Ignorant Patient?

By Girish Menon

My piece ‘Does Modern Medicine have a Platypus Problem?’ unleashed a 'minor storm in a teacup'. So, to improve my own understanding I write these words in the hope that some patient man will spare some time to clear my doubt.

In the immediate aftermath of my piece, a friend* suggested that using Dr, Immanuel's prescription to treat Covid was similar to using semen to cure Covid.

Another friend provided a slide showing the negative effect on countries not using HCQ. This data according to a third friend was fake news.

In the meantime:

The BBC carried an ad hominem article on Dr. Stella Immanuel stating that she was a pastor who had made wild claims about aliens in the past.

The WHO carried out a study which claimed that HCQ (hydroxychloroquine) was ineffective in the treatment of Covid. However, the WHO on the same page also stated " The decision to stop hydroxychloroquine’s use in the Solidarity trial does not apply to the use or evaluation of hydroxychloroquine in pre or post-exposure prophylaxis in patients exposed to COVID-19" (sic).


Yesterday another friend announced that her friend in Mumbai had recovered from Covid. During the illness she was given HCQ.

So, I asked this friend ‘does that mean HCQ cured her of Covid?’

She replied, ‘I don't know. She had tested negative for Covid. Her symptoms started with a rash which was not a symptom of Covid and yet her doctor diagnosed her condition as a Covid attack.’

So does this mean that at least there could be a positive correlation between HCQ and Covid treatment?’

‘I don't know’

‘Suppose you were in Mumbai, contracted Covid and a doctor you trust prescribed HCQ would you take it?’

‘Yes’

‘Now in a thought experiment, suppose you were teleported to Cambridge say four days later, still having Covid and the GP does not prescribe HCQ?’

‘I will obey the Milton physician.’


All these discussions reminded me of Omar Khayyam's "Myself when young did eagerly frequent doctor and saint, and heard great argument about it and about: but evermore came out by the same door as in I went."

And my questions remain:

What conclusion should a layman draw about HCQ and Covid?

Should I take HCQ as a prophylactic?

---

* All friends quoted in the article are related to science and medicine.

Saturday 29 April 2017

Whiplash: the myth that funds a £20bn gravy train

Patrick Collinson in The Guardian


Ten years ago I was in a country lane in Leicestershire, indicating to turn right to go into a hotel for a family event. Seconds later my car was a write-off after a young driver careered round the bend, smashing into the rear of my VW Golf. Fortunately I stepped out uninjured. And from that moment I was pestered, again and again, to make a false whiplash claim.

One of the hotel’s guests was first in. “You’ve got to get down the doctors, tell them your neck is really hurting. You’ll easily get £3,000,” said one (I’m summarising here). But my neck, while a little stiff, wasn’t in pain. Others told me I was mad not to apply. But a decade later there is no evidence the crash caused anything other than a mild sprain that lasted a couple of days. And certainly not deserving of the £3,000-£6,000 that is routinely paid out to “victims” of even the mildest of rear-end shunts.

Now one brave consultant neurosurgeon, who has carried out thousands of operations involving neck and back issues, has declared that whiplash is a myth, nothing more than a multibillion-pound gravy train for lawyers, doctors and the victims suffering from “mainly non-existent injuries”.

In a remarkable piece for the Irish Times, Dr Charles Marks, a lecturer at University College Cork, says the medical profession is as guilty as the lawyers. “For 20 years I wrote medical reports which were economical with the truth … the truth being, there was very little wrong with the vast majority of compensation claimants that I saw. I was moving with the herd.” In Ireland, where payouts have reached levels that even the most avaricious ambulance-chasing lawyer here can only dream of, a doctor can earn as much as £3,000 a week in fees after spending 20 minutes with someone involved in a minor car crash, then writing a largely templated report. “It’s a fee of around €350 and you can easily do 10 a week,” Marks says.

Yet whiplash is “almost impossible to prove”, says Dr Marks, with patients self-diagnosing pain that can never be detected using sophisticated imaging techniques such as MRI and bone scans. “All whiplash is minor. Moderate or permanent whiplash is simply non-existent.”

He cites one study of 40 “demolition derby” drivers in the US who had an average of 1,500 collisions each over a couple of years. Compare that to a mild shunt in slow-moving traffic that, somehow, warrants payouts of thousands. Yet just two of the demolition derby drivers reported post-participation neck pain that lasted more than three months.

Dr Marks adds that in Greece and Lithuania, where there is no expectation of financial gain from whiplash, chronic neck pain following a car crash appears simply not to exist.

But one (British) consultant in Ireland is barely sufficient evidence. So I spoke to another whiplash expert, Dr Stuart Matthews, consultant surgeon in major orthopaedic trauma at the Leeds Teaching Hospitals. He sounded even more dismissive than Dr Marks. “There is not a single test that shows abnormality directly attributable to this condition. Diagnoses are purely on the say-so of the person involved. Many orthopaedic surgeons do not believe it is a genuine condition.”

He says early research that provided medical endorsement for whiplash claims has subsequently been rejected. “It’s the emperor’s new clothes. People just go along with it, there is a bandwagon.”

Neck sprain is genuine, he says, but recovery is relatively quick with little evidence of significant physical injury.

Yet the victims of whiplash receive £2bn a year in payouts, a fair chunk of which goes to personal injury lawyers. That’s £20bn over the past decade, paid for out of galloping increases in car insurance premiums. The forthcoming election means that reforms to whiplash payouts, promised in the prison and courts bill, have been shelved.

A new government, of whatever complexion, should reinstate the reforms – and order a major medical review to determine if we have all been conned for years.

Thursday 5 May 2016

Medical Council of India similar to BCCI?

The Hindu


The Supreme Court has given the Centre a deserved rebuke by using its extraordinary powers and setting up a three-member committee headed by former Chief Justice of India R.M. Lodha to perform the statutory functions of the Medical Council of India. The government now has a year to restructure the MCI, the regulatory body for medical education and professional practice. The Centre’s approach to reforming the corruption-afflicted MCI has been wholly untenable; the Dr. Ranjit Roy Chaudhury expert committee that it set up and the Parliamentary Standing Committee on Health and Family Welfare in the Rajya Sabha had both recommended structural change through amendments to the Indian Medical Council Act. Now that the Lodha panel will steer the MCI, there is hope that key questions swept under the carpet at the council will be addressed quickly. Among the most important is the need to reduce the cost of medical education and increase access in different parts of the country. This must be done to improve the doctor-to-population ratio, which is one for every 1,674 persons, as per the parliamentary panel report, against the WHO-recommended one to 1,000. In fact, it may be even less functionally because not all registered professionals practice medicine. In reality, only people in bigger cities and towns have reasonable access to doctors and hospitals. Removing bottlenecks to starting colleges, such as conditions stipulating the possession of a vast extent of land and needlessly extensive infrastructure, will considerably rectify the imbalance, especially in under-served States. The primary criterion to set up a college should only be the availability of suitable facilities to impart quality medical education.

The development of health facilities has long been affected by a sharp asymmetry between undergraduate and postgraduate seats in medicine. There are only about 25,000 PG seats, against a capacity of 55,000 graduate seats. The Lodha committee is in a position to review this gap, and it can help the Centre expand the system, especially through not-for-profit initiatives. There is also the contentious issue of choosing a common entrance examination. Although the Supreme Court has allowed the National Eligibility-cum-Entrance Test, some States are raising genuine concerns about equity and access. A reform agenda for the MCI must include an admission procedure that eliminates multiplicity of entrance examinations and addresses issues such as the urban-rural divide and language barriers. The Centre’s lack of preparedness in this matter, even after it was deliberated by the parliamentary panel, is all too glaring. The single most important issue that the Lodha committee would have to address is corruption in medical education, in which the MCI is mired. Appointing prominent persons from various fields to a restructured council would shine the light of transparency, and save it from reverting to its image as an “exclusive club” of socially disconnected doctors.

Sunday 2 June 2013

Cancer medication as low as Rs 1,000/month on way

, TNN

MUMBAI: It's widely known that a month's dose of cancer drugs can cost lakhs, but what isn't common knowledge is that Tata Memorial Hospital's doctors are working on alternatives that could cost less than Rs 1,000 a month.

Dubbed the metronomic treatment protocol, it comprises daily consumption of a combination of low-dose medicines that are cheap because they have been around for decades. "There is no need to worry about patents or recovery of billions spent on research,'' said Dr Shripad Banavali, head of the medical oncology department of Tata Memorial Hospital, Parel, who has been working on the low-dose-low-cost therapies.

His colleague, Dr Surendra Shastri sums up the mood well: "The metronomics experiment is path-breaking in terms of providing good quality and affordable cancer care for a majority of the over 10 lakh cancer cases diagnosed in India each year.'' These findings could revolutionize cancer care in most developing countries, he said.

The catch is, however, that this branch is still in research stage. The conventional cancer treatment comprising chemotherapy is given at "maximum tolerated doses" which are tested and have reams of research to back it. As against this, in metronomic therapies, the drugs are given at very low doses. "But side-effects are fewer and patients have a good quality of life,'' said Dr Banavali.

The word metronomics is borrowed from music; musicians use the metronome to mark time and hence rhythm. Patients are asked to take these medicines for a period of 21 days or more before taking a break of a week; such a cycle continues for months.

Dr Banavali's work has been published in the May issue of the medical journal Lancet Oncology. Thousands of patients have been on metronomic treatment in Tata Memorial Hospital as well as its rural centre, with a sizeable number managing to control the growth of cancer. "In India, the main challenge in cancer is not just finding cures, but to develop affordable treatments'' he said.

In fact, the metronomic work arose out of such cost concerns over a decade back. The Tata doctors found that many patients were lost to treatment because they were overwhelmed by the cost of medicines. "Moreover, many patients came so late for treatment that we had to turn them away without any medicines,'' said Dr Banavali. Instead of turning away such patients, the Tata team decided to adopt the metronomic treatment as palliative treatment that was being tested out in various parts of the world. "We gave them drugs that would help in pain or at least ensure that their case doesn't worsen," he adds.

But the results surprised them. In a large group of children with blood cancers called acute myeloid leukemia (AML), they found that metronomic maintenance treatment had helped increased survival rate to 67%. The group then started its own innovation, going ahead of the rest of the world. "The West used the same set of medicines for all forms of cancer, but we introduced personalised medicines for various types of cancers,'' said Dr Banavali.

The Lancet paper, titled 'Has the time come for metronomics in low-income and middle-income countries', mentions combination of drugs used for four cancers (see box). The Tata doctors feel that these drugs may work as well for newly developed tumours. "While the developed world is going after 'drug discoveries', that is discovering new drugs which are very costly for our patients, we are going after 'drug repositioning', that is using time-tested drugs for the treatment of cancer," said Dr Banavali. For example they are using drugs likemetformin (an anti-diabetic drug), sodium valproate (an anti-seizure drug) and propranolol (an anti-hypertensive drug) in the treatment of cancer.

The Lancet paper said, "The combination of metronomic chemotherapy and drug repositioning might provide a way to overcome some of the major constraints associated with cancer treatment in developing countries and might represent a promising alternative strategy for patients with cancer living in low- and middle-income countries.''

Metronomics chemotherapy works at three levels. It attacks tumours while working on the "micro-environment", like the blood vessels, around the tumour. Thirdly, it works on the immuno-modulating system of the body. "Unless the metronomic dose works on all these three fields, it may not work,'' said the doctor.

Survivor of twin blows, counselor for others

On the occasion of Cancer Survivors Day on June 2, members of Ugam, an NGO, will put up a skit at Tata Memorial Hospital to underline the problems of parents whose children suffer from cancer. Comprising childhood cancer survivors, Ugam members counsel cancer patients undergoing treatment at Tata Memorial Hospital. One of its founder members, Shalaka Mane (29), who lost her right eye to cancer, will be there too. She feels people discriminate against cancer patients. "I feel there is a need to increase awareness about the treatment of cancer in society and the government, and enable these families to get financial help," she says. Diagnosed with blood cancer when she was eight years old, she barely got back to being at the top of her class when she was found to have brain cancer. "I was in Class XII and planning to take up medicine, but it wasn't to be,'' she says. The second cancer was so virulent that she lost her eye. But she emerged victorious a second time and completed her masters. She now teaches at Kalvidhai Mission High School, Andheri, which she attended as a student. "My principal and teachers never discriminated against me because of my illness. I enjoy my job," she adds.

'Cancer can't affect my future'

Artist Sachin Chandorkar is a poster boy of sorts at the Tata Memorial Hospital, Parel. At 28, he has won several awards (one from chief minister Prithviraj Chavan last month) for his murals and sculptures. But the Tata connection comes from his victory over cancer when he was five years of age. He was suffering from Hodgkin's Lymphoma. "I remember feeling irritated due to the itch on my head. When I would stratch my head, tufts of hair would come into my hands. I would then start crying," says Chandorkar, who studied at the JJ School of Arts. He usually doesn't talk about his battle with the Big C. "When my mother and sisters sometimes talk about it, I ask them to stop. I have decided that cancer is a part of my past and cannot affect my future,'' he adds.

Saturday 18 May 2013

Medical intervention is not always the answer to mental health issues









by Frank Furedi

 The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders has just been published and the contents of this book should really be of interest to you. The DSM is not simply a medical handbook that provides a list of conditions worthy of the diagnosis of mental illness. It is also a secular bible that instructs people how to make sense of their predicament through the language of medicine.

With every edition of the DSM, the number of conditions diagnosed as a problem suitable for psychiatric intervention expands. You, dear reader, may be suffering from a mental illness that you never knew existed. So if like me you really get angry now and then, the DSM suggests that you may be suffering from “disruptive mood dysregulation disorder”. Or if you have the occasional senior moment, you may well be afflicted with the new diagnosis of “mild neurocognitive disorder”. And if you really feel anxious and scared about experiencing pain and discomfort, you may have “somatic symptom disorder”.
The eccentric loner, the shy stranger lacking in social skills, the naughty child, anyone who eats too much or the sexually confused teenager have all become candidates for the psychiatrist’s couch. What’s important about the DSM is that it provides a language and narrative through which the problems of existence become medicalised. And in a world where a medical diagnosis represents a claim for resources, what the DSM says really matters. The verdict of the DSM not only affects insurance and drug companies interested in their bottom line but also anxious parents who rely on a diagnosis to gain special help for their child.
Not surprisingly, the latest edition of the DSM has become a subject of controversy. Different groups of medics and psychiatrists have questioned the scientific reliability of some of the new diagnostic categories. Some have queried the dropping of the category of Asperger’s syndromeand the decision to include it under a general autism diagnosis. Others argue that the psychiatric lobby has become a captive of the pharmaceutical industry. But what is not at issue is the ethos of medicalisation promoted through this influential manual.
The term medicalisation refers to the cultural process through which a range of human experience is reinterpreted through the language of medicine. In recent decades, many everyday experiences have become redefined as issues of health that require medical intervention. Through reinterpreting existential problems such as loneliness, shyness, fear, anxiety, loss of control or grief as medical ones, the meaning people attach to them fundamentally alters.
Medical problems require treatment and rely on professional intervention to cure the patient’s illness. But why should grief or shyness or even anger be treated as a disease? And why should professionals possess a monopoly on how to interpret the pain and disappointment that people experience at different stages of their lives? The real threat posed by the expansion of mental health diagnosis is that it takes away from people the confidence that they need to make sense and give meaning to their personal experience.
The problem is not that professional advice is always misguided, but that it short-circuits the process through which people can learn how to deal with problems through their own experience. Intuition and insight gained from experience are continually compromised by professional knowledge. This has the unintentional consequence of estranging people from their own feelings and instincts since such reactions require the affirmation of the expert. In such circumstances, people’s capacity to handle relationships and to have confidence in their relationships diminishes further. In turn, this creates new opportunities for professional intervention in everyday life.
The manner in which emotional problems have become diagnosed as a form of disorder raises questions about the ability of the individual to deal with disappointment, misfortune, adversity or even the challenge of everyday life. And, sadly, when people are continually invited to make sense of their troubles through the medium of therapeutics, it severely undermines their resilience.
Once the diagnosis of illness is systematically offered as an interpretative guide for making sense of distress, people are far more likely to perceive themselves as ill. That is one reason why in Western society the number of people diagnosed as suffering from mental illness has risen exponentially. The explanation for this trend lies not in the fields of epidemiology, but in the realm of culture that invites people to classify themselves as infirm.
Recently, the British Psychological Society’s division of clinical psychology has attacked the psychiatric profession for offering a biomedical model for understanding mental distress. But its criticism was not directed at the ethos of medicalisation as such, but only at the tendency to associate mental illness with biological causes. What it offered was an alternative model of medicalisation – one where mental illness was represented as the outcome of social and psychological cause. It seems that medicalisation has become so deeply entrenched that even critics of the DSM accept its premise.
The problems of life can be painful. But this experience of existential agony must not be rebranded as an illness. Medicalisation empties experience of its creative content and assigns human beings the status of permanent patients. The promiscuous expansion of diagnosis also trivialises mental illness. Learning to distinguish between normal suffering and illness is a mark of a mature and confident culture.
Frank Furedi is a sociologist whose books include ‘Therapy Culture’

Thursday 14 March 2013

Your five worst medical nightmares



From a doctor amputating the wrong leg, to a woman given the wrong baby, hospital treatment does not always go to plan. Luckily, though, mistakes are rare
Carry on Doctor
One unhappy patient … Kenneth Williams in the 1967 film Carry on Doctor. Photograph: ITV/Rex Features
It sounds like a classic nightmare – waking up during an operation to find you can't move. But that's what happened to one patient, Sarah Newton. "I was trying to scream. I tried to wiggle my toes desperately hard but I couldn't move anything." Thankfully, "accidental awareness", as it is known, is rare. A survey from the Royal College of Anaesthetists says it occurs once in every 15,000 operations under general anaesthetic, or 153 times in 2011 – and is usually brief and painless. But what of our other medical terrors?

Wrong site surgery

Usually the cause is a catastrophic series of administrative errors, such as when Dr Rolando Sanchez, a Florida surgeon, was told by a nurse that he was amputating the wrong leg of his patient just as he finished cutting through it. Luckily, with only 70 incidents recorded by the NHS in the year 2011-12, it is extremely unusual.

Wrong patient surgery

Never mind the wrong limb. How about operating on the wrong body? Sometimes there may be a mix-up over two people with the same name. Or similar procedures. The reality may not be as scary as it sounds – recently a patient in Cambridgeshire was given another patient's lens during eye surgery, although this was soon corrected. Plus there were fewer than 10 incidents reported in the UK during 2011-2.

Retained instruments

Leaving surgical instruments inside patients occurred 161 times in 2011-12. Often it's a sponge, which can lead to serious infections. The risk arises in emergency surgery, and in surgery on obese patients, but it is still very unlikely to happen to you.

Baby mix-ups

Despite being a common storyline in films or stories, there are few documented cases of mothers sent home with the wrong baby. But you have to ask: how would they know? In Romania in 2008, Cristina Zahariuc noticed because the daughter she was sent home with turned out to have a penis. Despite a few awful stories, the risk will be lower now that most babies stay with their parents immediately after birth.

Being treated by an impostor

Well, it has happened. In September 2011, 17-year-old Matthew Scheidt was convicted, of impersonating a physician's assistant in Florida. He dressed wounds, attended surgery, examined naked patients and even administered CPR. While New Zealander Richmal Oates-Whitehead treated victims of the 7 July 2005 bombings in London, despite not being medically qualified.
Ferdinand Waldo Demara managed fairly well when he conducted a series of major operations by speed-reading textbooks during the Korean war. And a man called Gerald Barnes even managed to impersonate a doctor, and be convicted of it, five times. Thankfully pretenders do tend to get caught.